Functional interaction between Mus81-Mms4 and Rad52 in Saccharomyces cerevisiae
Tóm tắt
Mus81-Mms4 is a well conserved DNA structure–specific endonuclease and efficiently cleaves different DNA structures that could arise during the repair of stalled/blocked replication forks and homologous recombination repair. Rad52 is an ezyme that stimulates main steps of DNA sequence-homology searching. In this study, we proved that Rad52 and Mus81-Mms4 possess a species-specific functional interaction, indicating that Rad52 and Mus81-Mms4 collaborate in processing of homologous recombination intermediates.
Từ khóa
functional interaction, homologous recombination, Mus81, Rad52.
Toàn văn:
PDFDOI: https://doi.org/10.54607/hcmue.js.14.9.294(2017)
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