Synthesis of some mono and dialkynyl derivatives containing thieno[3,2-b]thiophene ring via Sonogashira alkynylation reaction

Tóm tắt

The Sonogashira cross-coupling reactions were used to synthesize 5 new monoalkynyl derivatives (10a-e) and 2 dialkynyl derivatives (12a-b) containing thieno[3,2-b]thiophene from monoaryl thieno[3,2-b]thiophen in moderate yield. The procedure was optimized and triphenylphosphine (0.2 eq.), palladium diacetate (0.1 eq), copper (I) iodide (0.2 eq.), THF, iPr₂NH were found to be the best in these cases. The structures of the (10a-e) and (12a-b) compounds were elucidated by ¹H and ¹³C NMR and mass spectral analysis.